The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. We plan to examine whether patients who did not tolerate cetirizine due to sedation are able to tolerate levocetirizine. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. Listing a study does not mean it has been evaluated by the U. This study will utilize a randomized, double-blind, placebo controlled trial comparing levocetirizine, cetirizine, and placebo in regards to sedation and allergy symptom scores. Because of their toxicity, bromides were replaced by barbiturates in the early 20th century, which were initially also heralded as effective and safe sedative drugs.However, in a short period of time problems with dependence, tolerance and lethal overdosing became evident.Attempts to find sedatives other than alcohol for treating anxiety and nervousness began in the 19th century with the introduction of bromides, which were discovered in 1826.These drugs were extremely popular for this purpose until their propensity to build up in the body and produce toxic effects became known in the medical community.Also can be used during a long term brain EEG to help patient relax.
Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Before using sedation, doctors try to identify any of the following that may apply: known drug allergies and sensitivities, hypertension, heart defects, kidney disease, other allergens, such as latex allergy, history of stroke or transient ischemic attack (TIA) (certain oral sedation methods may trigger a TIA), neuromuscular disorders (such as muscular dystrophy), or a current list of medications and herbal supplements taken by the patient.A patient with any of these conditions must be evaluated for special procedures to minimize the risk of patient injury due to the sedation method.Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.Examples of drugs which can be used for sedation include isoflurane, propofol, etomidate, ketamine, fentanyl, lorazepam and midazolam.