Dating the emergence of pandemic influenza

Mean estimates of the time of most recent common ancestor also suggest that the H2N2 and H3N2 pandemic strains may have been generated through reassortment events in unknown mammalian hosts and involved multiple avian viruses preceding pandemic recognition.

The possible generation of pandemic strains through a series of reassortment events in mammals over a period of years before pandemic recognition suggests that appropriate surveillance strategies for detection of precursor viruses may abort future pandemics.

They are now known to represent 3 different antigenic subtypes of influenza A virus: H1N1, H2N2, and H3N2, respectively.

Not classified as true pandemics are 3 notable epidemics: a pseudopandemic in 1947 with low death rates, an epidemic in 1977 that was a pandemic in children, and an abortive epidemic of swine influenza in 1976 that was feared to have pandemic potential.

Epidemiologic-epizootiologic evidence strongly suggested that the causative virus was moving from humans to swine rather than in the reverse direction.

Similar observations were made on the other side of the world and reported in a little-known paper in the National Medical Journal of China ().

TY - JOURT1 - Dating the emergence of pandemic influenza viruses AU - Smith, Gavin J. AU - Bahl, Justin AU - Vijaykrishna, Dhanasekaran AU - Zhang, Jinxia AU - Poon, Leo L. Despite global concern regarding a new pandemic influenza, the emergence pathway of pandemic strains remains unknown.

Each differed from the others with respect to etiologic agents, epidemiology, and disease severity. In the case of the 2 that occurred within the era of modern virology (19), the hemagglutinin (HA) antigen of the causative viruses showed major changes from the corresponding antigens of immediately antecedent strains. Google(); req('single_work'); $('.js-splash-single-step-signup-download-button').one('click', function(e){ req_and_ready('single_work', function() ); new c. You may now see our list and photos of women who are in your area and meet your preferences.AB - Pandemic influenza viruses cause significant mortality in humans.KW - H1N1KW - Influenza AKW - Molecular clock KW - Swine KW - Virus evolution UR -

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